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Doctoral Candidate (dc8) – Novel Probes For Imaging Of Tumor-associated Cathepsins Via Positron...,

Publicados 2022-06-28
Expira 2022-07-28
ID #1064168311
Free
Doctoral Candidate (dc8) – Novel Probes For Imaging Of Tumor-associated Cathepsins Via Positron...,
Portugal, Portalegre, Portugal,
Publicados June 28, 2022

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Tipo de emprego: Tempo total
Tipo de contrato: Permanente
Tipo de salário: Por mês
Ocupação: Doctoral candidate (dc8) – novel probes for imaging of tumor-associated cathepsins via positron...


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OFFER DESCRIPTION The Doctoral Candidate (DC8) – Novel probes for imaging of tumor-associated cathepsins via Positron Emission Tomography (PET) and fluorescence microscopyTasks descriptionThis interdisciplinary doctoral position is jointly hosted by the Medicinal Chemistry and Medicinal Organic Chemistry groups at the Faculty of Pharmacy of the University of Lisbon (FFUL). Both groups have expertise in bioactive compound discovery and optimization, among others in protease inhibitors and derived tool compounds. In this position, you will: Design, synthesize and characterize novel cathepsin ligands, transform optimal ligands into radiolabeled, fluorescent and biotinylated derivatives and evaluate the best CatB and CatL PET probes in a CT26 modelPerform organic synthesis, as well as analytical and biological investigations on the compounds.Write project reports for your local and network supervisors on a regular basisEnroll in the Pharmacy Doctoral School at FFUL and comply with Pharmacy’s doctoral training requirements.Participate actively to OncoProTools’ training, dissemination, communication and valorization program.Prepare a doctoral thesis, and publish scientific articles related to the research project. Furthermore, the selected candidate will take part in the following planned secondments: Academic secondment to University of Antwerp (4 months, Belgium) to evaluate the CatB and CatL PET probes in the CT26 model.Industrial secondment at CROMed (4 months, Hungary) for PET quantification of CatB in the CT26 model during CAR T treatment. Profile & requirements Applicants must hold a master’s degree or equivalent in the field of (Bio-) Chemistry, Pharmaceutical Sciences or equivalent.Master students in their final year may apply Transcripts of the master’s degree should be obtained before signing the contract.Applicants must have a solid knowledge of organic chemistry and medicinal chemistry.Applicants have obtained outstanding academic results.Applicants must have an ability to understand and express themselves in both written and spoken English to a level that is sufficiently high for them to derive the full benefit from the network training.Applicants must be eligible to enrol on a PhD programme at the host institution.Applicants must have the necessary academic skills and background to make the success of a doctoral degree.Applicants can be of any nationality but must comply with the Horizon Europe MSCA eligibility criteria: HORIZON MSCA Mobility Rule: researchers must not have resided or carried out their main activity (work, studies, etc.) in the country of the host organisation for more than 12 months in the 3 years immediately before the recruitment date. Compulsory national service, short stays such as holidays and time spent by the researcher as part of a procedure for obtaining refugee status under the Geneva Convention are not taken into account.HORIZON MSCA eligibility criteria: supported researchers must be doctoral candidates, not already in possession of a doctoral degree at the date of the recruitment. Researchers who have successfully defended their doctoral thesis but who have not yet formally been awarded the doctoral degree will not be considered eligible. Benefits The selected candidate will be employed by the host organisation for 36 months. In line with Faculty of Pharmacy regulations and following a positive evaluation by the doctoral committee, the host institution may provide additional funding for a maximum of 12 months to complete a doctoral degree.The start date will be from January, 1st 2023 onwards. FFUL has received the following EU-grant to recruit a Doctoral Candidate (DC): monthly Living Allowance € monthly Mobility Allowance € 600; and monthly Family Allowance € 660 (only if applicable). Please note that the final monthly, gross salary will result from deducting (from the mentioned amounts) all compulsory national labour taxes (social security, etc.) to be borne by the employer FFUL). More information: The opportunity to be part of an MSCA Doctoral Network: the selected candidate will benefit from the designed training programme offered by the host organisation and the OncoProTools consortium.The selected candidate will participate in international secondments to other organisations within the OncoProTools network and in outreach activities targeted at a wide audience.Please, find additional information in the Horizon Europe Work Programme MSCA from onwards. More Information Additional Information BenefitsBenefits The selected candidate will be employed by the host organisation for 36 months. In line with Faculty of Pharmacy regulations and following a positive evaluation by the doctoral committee, the host institution may provide additional funding for a maximum of 12 months to complete a doctoral degree.The start date will be from January, 1st 2023 onwards.FFUL has received the following EU-grant to recruit a Doctoral Candidate (DC): monthly Living Allowance € monthly Mobility Allowance € 600; and monthly Family Allowance € 660 (only if applicable). Please note that the final monthly, gross salary will result from deducting (from the mentioned amounts) all compulsory national labour taxes (social security, etc.) to be borne by the employer FFUL). More information: The opportunity to be part of an MSCA Doctoral Network: the selected candidate will benefit from the designed training programme offered by the host organisation and the OncoProTools consortium.The selected candidate will participate in international secondments to other organisations within the OncoProTools network and in outreach activities targeted at a wide audience. Please, find additional information in the Horizon Europe Work Programme MSCA from onwards.Requirements Offer Requirements REQUIRED EDUCATION LEVEL Chemistry: Master Degree or equivalent Pharmacological sciences: Master Degree or equivalent REQUIRED LANGUAGES ENGLISH: Excellent Skills/QualificationsProfile & requirements Applicants must hold a master’s degree or equivalent in the field of (Bio-) Chemistry, Pharmaceutical Sciences or equivalent.Master students in their final year may apply Transcripts of the master’s degree should be obtained before signing the contract.Applicants must have a solid knowledge of organic chemistry and medicinal chemistry.Applicants have obtained outstanding academic results.Applicants must have an ability to understand and express themselves in both written and spoken English to a level that is sufficiently high for them to derive the full benefit from the network training.Applicants must be eligible to enrol on a PhD programme at the host institution.Applicants must have the necessary academic skills and background to make the success of a doctoral degree.

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    Universidade De Lisboa (ulisboa)
    Registrado em October 7, 2017

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    Portugal (português: [puɾtuˈɣal]), oficialmente a República Portuguesa (português: República Portuguesa [ʁɛˈpuβlikɐ puɾtuˈɣezɐ]), é um país localizado principalmente na Península Ibérica, no sudoeste da Europa. É o estado soberano mais ocidental da Europa continental, sendo limitado a oeste e a sul pelo Oceano Atlântico e a norte e a leste pela Espanha. O seu território inclui também os arquipélagos atlânticos dos Açores e da Madeira, ambas regiões autónomas com governos regionais próprios. A língua oficial e nacional é o português. Portugal é o mais antigo Estado-nação da Península Ibérica e um dos mais antigos da Europa, tendo o seu território sido continuamente povoado, invadido e disputado desde a pré-história. Habitada por povos pré-célticos e célticos, visitados por fenícios-cartagineses, gregos antigos e governados pelos romanos, a quem se seguiram as invasões dos povos suebi e visigodos germânicos. Após a conquista muçulmana da Península Ibérica, a maior parte de seu território fazia parte de Al-Andalus. Portugal como país foi estabelecido durante a primeira Reconquista Cristã. Fundado em 868, o Concelho de Portugal ganhou destaque após a Batalha de São Mamede (1128). O Reino de Portugal foi posteriormente proclamado após a Batalha de Ourique (1139), e a independência de Leão foi reconhecida pelo Tratado de Zamora (1143). Nos séculos 15 e 16, Portugal estabeleceu o primeiro império marítimo e comercial global, tornando-se um das principais potências econômicas, políticas e militares do mundo. Durante este período, hoje conhecido como a Era dos Descobrimentos, os exploradores portugueses foram os pioneiros da exploração marítima, notadamente sob o patrocínio real do Príncipe Henrique, o Navegador e do Rei João II, com viagens notáveis ​​como a de Bartolomeu Dias para além do Cabo da Boa Esperança (1488 ), A descoberta de Vasco da Gama da rota marítima para a Índia (1497-1498) e a descoberta europeia do que viria a ser o Brasil (1500). Durante este tempo, Portugal monopolizou o comércio de especiarias, dividiu o mundo em hemisférios de domínio com Castela, e o império se expandiu com campanhas militares na Ásia. No entanto, eventos como o terremoto de Lisboa de 1755, a ocupação do país durante as Guerras Napoleônicas e a independência do Brasil (1822) apagaram em grande medida a opulência anterior de Portugal. Após a revolução de 1910 depôs a monarquia, a democrática mas instável Primeira República Portuguesa foi instituído, sendo posteriormente substituído pelo regime autoritário do Estado Novo. A democracia foi restaurada após a Revolução dos Cravos (1974), encerrando a Guerra Colonial Portuguesa. Pouco depois, a independência foi concedida a quase todos os seus territórios ultramarinos. A transferência de Macau para a China (1999) marcou o fim do que pode ser considerado um dos mais longevos impérios coloniais. Portugal deixou uma profunda influência cultural, arquitetônica e linguística em todo o mundo, com um legado de cerca de 250 milhões de falantes de português, e muitos crioulos baseados no português. É um país desenvolvido com uma economia avançada e elevados padrões de vida. Além disso, está bem colocado nas classificações de liberdade moral (2 °), paz (3 °), democracia (7 °), liberdade de imprensa (10 °), estabilidade (15 °), progresso social (18 °) e prosperidade (26 °). Membro das Nações Unidas e da União Europeia, Portugal foi também um dos membros fundadores da NATO, da zona euro, da OCDE e da Comunidade dos Países de Língua Portuguesa.

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